Structure and antitumour activity of fucoidan isolated from sporophyll of Korean brown seaweed Undaria pinnatifida
نویسندگان
چکیده
Department of Carbohydrate Chemistry and Technology, Institute of Chemical Technology in Prague, Technická 5, 166 28 Prague 6, Czech Republic Department of Analytical Chemistry, Institute of Chemical Technology in Prague, Technická 5, 166 28 Prague 6, Czech Republic Department of Meat Technology and Preservation, Institute of Chemical Technology in Prague, Technická 5, 166 28 Prague 6, Czech Republic d Institute of Organic Chemistry and Biochemistry AS CR, Flemingovo sq. 2, 166 28 Prague 6, Czech Republic Department of Biotechnology, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 420-743, Republic of Korea
منابع مشابه
Anti-Proliferation Potential and Content of Fucoidan Extracted from Sporophyll of New Zealand Undaria pinnatifida
Undaria pinnatifida is a species of brown seaweed known to contain rich amounts of fucoidan, a sulfated polysaccharide known to possess various biological activities. We isolated crude fucoidan (F0) from the sporophylls of U. pinnatifida grown in the Marlborough Sounds, New Zealand. Sulfate content, uronic acid content, and molecular weight of F0 were 15.02, 1.24, and >150 kDa, respectively. F0...
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Brown seaweeds are thought to be beneficial to the human health, but little is known about their functional abilities to manage the blood pressure. Then, the effects of the extracts prepared from sporophyll, stem and leaf of brown seaweed Undaria pinnatifida on angiotensin I-converting enzyme (ACE) were examined to assess their antihypertensive activities. The extracts inhibited the enzyme acti...
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Structural characterization and antiviral activities of fucoidan from sporophyll of Undaria pinnatifida (Mekabu) was examined. The fucoidan was composed of fucose and galactose with an approximately ratio of 1.0:1.1. Degree of substitution of sulfate was 0.72 and its apparent molecular weight was 9,000. Methylation analyses showed that fucoidan had various sugar linkages, and revealed that the ...
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Fucoidans, fucose-enriched sulfated polysaccharides isolated from brown algae and marine invertebrates, have been shown to exert anticancer activity in several types of human cancer, including leukemia and breast cancer and in lung adenocarcinoma cells. In the present study, the anticancer activity of the fucoidan extracted from the brown seaweed Undaria pinnatifida was investigated in human he...
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Fucoidan from Mekabu (sporophyll of Undaria pinnatifida), a dietary alga, exerts antitumor activity possibly through enhancing the immune response. The present report describes the effects of dietary Mekabu fucoidan on the tumor growth of mouse A20 leukemia cells and on T cell-mediated immune responses in T cell receptor transgenic (DO-11 - 10 - Tg) mice. The animals were fed with a diet contai...
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